A dual function ofphyllopodinDrosophilaexternal sensory organ development: cell fate specification of sensory organ precursor and its progeny
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چکیده
منابع مشابه
A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila.
Su(H)/CBF1 is a key component of the evolutionary conserved Notch signalling pathway. It is a transcription factor that acts as a repressor in the absence of the Notch signal. If Notch signalling is activated, it associates with the released intracellular domain of the Notch receptor and acts as an activator of transcription. During the development of the mechanosensory bristles of Drosophila, ...
متن کاملSanpodo controls sensory organ precursor fate by directing Notch trafficking and binding γ-secretase
In Drosophila peripheral neurogenesis, Notch controls cell fates in sensory organ precursor (SOP) cells. SOPs undergo asymmetric cell division by segregating Numb, which inhibits Notch signaling, into the pIIb daughter cell after cytokinesis. In contrast, in the pIIa daughter cell, Notch is activated and requires Sanpodo, but its mechanism of action has not been elucidated. As Sanpodo is presen...
متن کاملLaser Microdissection of Sensory Organ Precursor Cells of Drosophila Microchaetes
BACKGROUND In Drosophila, each external sensory organ originates from the division of a unique precursor cell (the sensory organ precursor cell or SOP). Each SOP is specified from a cluster of equivalent cells, called a proneural cluster, all of them competent to become SOP. Although, it is well known how SOP cells are selected from proneural clusters, little is known about the downstream genes...
متن کاملGain-of-function alleles of Bearded interfere with alternative cell fate decisions in Drosophila adult sensory organ development.
We have isolated a novel class of gain-of-function mutations at the Bearded (Brd) locus which specifically affect the development of adult sensory organs in Drosophila. These Brd alleles cause bristle multiplication and bristle loss phenotypes resembling those described for the neurogenic genes Notch (N) and Delta (Dl). We have found that supernumerary sensory organ precursor (SOP) cells develo...
متن کاملRoles of miR-182 in sensory organ development and cancer
Micro ribonucleic acids (miRNAs) are a cluster of small non-coding RNA molecules predicted to regulate more than 30% of coding messenger (m)RNAs in the human genome and proven to be essential in developmental and pathological processes. The miR-182 gene was first found to be abundantly expressed in sensory organs and regulates the development of the retina and inner ear. Further studies reveale...
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ژورنال
عنوان ژورنال: Development
سال: 2001
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.128.14.2699